| Bioactivity | 8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2]. |
| Target | PKA |
| Invitro | 8-Bromo-cAMP (0.1/0.5 mM) 可增强人新生儿包皮成纤维细胞 (HFF1) 细胞的重编程效率，0.1 mM 8-Bromo-cAMP 与丙戊酸 (HY-10585) (0.5 mM) 具有协同作用 [1]。8-Bromo-cAMP (20 μM，24 和 48 小时) 诱导食管癌细胞系 (Eca-109) 凋亡[2]。8-Bromo-cAMP (0.5 mM，2 天) 诱导人子宫内膜基质细胞蜕膜化[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 8-Bromo-cAMP 相关抗体: |
| In Vivo | 8-Bromo-cAMP (60 mg/kg/天，腹腔注射，7 天) 可减少 CT26 肿瘤小鼠的肿瘤[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 23583-48-4 |
| Formula | C10H11BrN5O6P |
| Molar Mass | 408.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41. [2]. Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42. [3]. Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50(10):1-11. [4]. Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774 |
8-Bromo-cAMP
CAS: 23583-48-4 F: C10H11BrN5O6P W: 408.10
8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAM
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.