8-Br-7-CH-ADPR_product_DataBase

CAS: 1011457-95-6 F: C16H23BrN4O14P2 W: 637.22

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activa

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Bioactivity	8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes[1].
CAS	1011457-95-6
Formula	C16H23BrN4O14P2
Molar Mass	637.22
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Moreau, et al. Structure–activity relationship of adenosine 5′-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists. Journal of Medicinal Chemistry 56.24 (2013): 10079-10102.

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