| Bioactivity | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1]. |
| Invitro | 7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17[1]。 |
| In Vivo | 7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17[1]。 |
| Name | 7ß,27-Dihydroxycholesterol |
| CAS | 240129-43-5 |
| Formula | C27H46O3 |
| Molar Mass | 418.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. |
7ß,27-Dihydroxycholesterol
CAS: 240129-43-5 F: C27H46O3 W: 418.65
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycho
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