| Bioactivity | 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1]. |
| Target | protein kinase R (PKR) |
| Name | 7DG |
| CAS | 26927-01-5 |
| Formula | C26H30O5 |
| Molar Mass | 422.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9(6):398-405. [2]. Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288(22):6365-6391. |