7-Hydroxyneolamellarin A_product_DataBase

Bioactivity	7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1].
Invitro	7-Hydroxyneolamellarin A (0-150 μM; 12 h; Hela 细胞, MCF-7 细胞和 4T1 细胞) 抑制 HIF-1 信号通路，具有低细胞毒性[1]。7-Hydroxyneolamellarin A (0-100 μM; 12 h) 以剂量依赖性方式降低 Hela 细胞中 VEGF 的 mRNA 水平[1]。7-hydroxyneolamellarin A (0-50 μM; 36 h) 抑制 Hela 细胞迁移、侵袭和增殖[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	7-Hydroxyneolamellarin A (15 mg/kg; i.v.; 具有 4T1 细胞异种移植物的 BALB/c 小鼠) 抑制体内肿瘤生长[1]。 Animal Model:
Name	7-Hydroxyneolamellarin A
CAS	959662-26-1
Formula	C24H19NO5
Molar Mass	401.41
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338.

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