7-Fluorotryptamine hydrochloride_product_DataBase

Bioactivity	7-Fluorotryptamine hydrochloride is a potent agonist of GPRC5A. 7-Fluorotryptamine hydrochloride induces GPRC5A-mediated β-arrestin recruitment. 7-Fluorotryptamine hydrochloride can be used for research of immune and cancer signaling[1].
Target	GPRC5A
Invitro	在 PRESTO-Tango assay 中，7-Fluorotryptamine (100 μM) hydrochloride诱导 GPRC5A 招募 β-arrestin [1]。7-Fluorotryptamine (50 μM, 8 h) hydrochloride 与 TNFα 联合处理可下调 WT 和 GPRC5A-KO 细胞中的 TNFα 诱导产生的基因 (例如: IL41A、CXCL10、CSF2)[1]。7-Fluorotryptamine (0-100 μM, 16 h) hydrochloride 对哺乳动物细胞 (HTLA、HT-29 细胞) 没有毒性[1]。
Name	7-Fluorotryptamine hydrochloride
CAS	159730-09-3
Formula	C10H12ClFN2
Molar Mass	214.67
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Zhao X, et al. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A. Nat Chem Biol. 2023 May 29.

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