| Bioactivity | 7-BIA is a receptor-type protein tyrosine phosphatase D (PTPRD) inhibitor with an IC50 of ~1-3 μM[1]. | ||||||||||||
| Target | IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS) | ||||||||||||
| Invitro | 7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC50 values of ~1–3 μM and 40 μM, respectively[1]. | ||||||||||||
| In Vivo | 7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice[1]. Animal Model: | ||||||||||||
| Name | 7-BIA | ||||||||||||
| CAS | 1313403-49-4 | ||||||||||||
| Formula | C15H18O6 | ||||||||||||
| Molar Mass | 294.30 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Uhl GR, et al. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosinephosphatase D (PTPRD) and by a novel PTPRD antagonist. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11597-11602. |