| Bioactivity | 6PGD-IN-1 (compound S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD). IC50 and Kd the value of 17.8μM and 17.1 μM respectively. 6PGD-IN-1 has antitumor activity[1]. |
| Invitro | 6PGD-IN-1 (10-40 μM, 24-72 h) 可抑制 H1299 和 K562 的细胞活力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 6PGD-IN-1 相关抗体: |
| In Vivo | 6PGD-IN-1 (20 mg/kg/day, 腹腔注射, 连续 4 周) 在皮下注射 H1299 细胞的异种移植裸鼠中可降低肿瘤生长和体积[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 5539-66-2 |
| Formula | C15H10O4 |
| Molar Mass | 254.24 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96. |