6-O-Isobutyrylbritannilactone_product_DataBase

Bioactivity	6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].
Invitro	6-O-Isobutyrylbritannilactone (5-100 μM; 48 h) 对 IBMX (100 μM; 24 h)[1]。6-O-Isobutyrylbritannilactone (5-30 μM; 12 h) 剂量依赖性地抑制 IBMX 刺激 B16F10 细胞的白化相关 mRNA 水平 (100 μM; 48 h)[1]。6-O-Isobutyrylbritannilactone (20 μM; 1-9 h) 时间依赖性地抑制 ERK、AKT 和 CREB 的磷酸化[1]。 RT-PCR[1] Cell Line:
In Vivo	6-O-Isobutyrylbritannilactone (10-100 μM; 48 h) 与未处理的对照组相比，显著减少斑马鱼胚胎中的色素沉着[1]。 Animal Model:
Name	6-O-Isobutyrylbritannilactone
CAS	1259933-02-2
Formula	C19H28O5
Molar Mass	336.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jang DK, et al. Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models. Molecules. 2020 Aug 26;25(17):3887.

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