| Bioactivity | 6-Methylcoumarin is a synthetic fragrance widely used in cosmetics. | ||||||||||||
| Invitro | 6-Methylcoumarin is reported to be almost nonphototoxic in epidermal tissue and cell culture phototoxicity test models. HaCaT cells are treated with 6-Methylcoumarin (1-105 nM) and/or UVA (5 J cm-2), and γ-H2AX is detected by immunofluorescence staining and western blotting 4hours after the treatments. 6-Methylcoumarin clearly produces γ-H2AX-positive cells under UVA irradiation from a concentration of 100 nM[1]. | ||||||||||||
| Name | 6-Methylcoumarin | ||||||||||||
| CAS | 92-48-8 | ||||||||||||
| Formula | C10H8O2 | ||||||||||||
| Molar Mass | 160.17 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Toyooka T, et al. Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity. J Invest Dermatol. 2011 Jun;131(6):1313-21. |