| Bioactivity | 6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits ASIC3-mediated currents from rat dorsal root ganglion neurons with an IC50 of 230 nM[1]. |
| Target | IC50: 88 nM (ASIC1) |
| Name | 6-Iodoamiloride |
| CAS | 60398-23-4 |
| Formula | C6H8IN7O |
| Molar Mass | 321.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rocio K Finol-Urdaneta, et al. Automated Patch Clamp Screening of Amiloride and 5- N, N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor. Mol Pharm. 2023 Jul 3;20(7):3367-3379. |
6-Iodoamiloride
CAS: 60398-23-4 F: C6H8IN7O W: 321.08
6-Iodoamiloride is a potent acid-sensing ion channel 1 (ASIC1) inhibitor with an IC50 of 88 nM. 6-Iodoamiloride inhibits
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