| Bioactivity | 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research[1]. | ||||||
| Sequence | 6-FAM-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys (Disulfide bridge: Cys3-Cys35,Cys12-Cys28,Cys17-Cys32) | ||||||
| Shortening | 6-FAM-AEEAc-RSCIDTIPKSRCTAFQCKHSMKYRLSFCRKTCGTC (Disulfide bridge: Cys3-Cys35,Cys12-Cys28,Cys17-Cys32) | ||||||
| Formula | C196H295N55O57S7.xCHF3O2 | ||||||
| Molar Mass | 4558.23 (free acid) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Devaux, et al. "Tight junctions potentiate the insulative properties of small CNS myelinated axons." The Journal of cell biology 183.5 (2008): 909-921. |
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) (TFA)
CAS: F: C196H295N55O57S7.xCHF3O2 W: 4558.23 (free acid)
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with
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