| Bioactivity | 6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase)[1]. |
| Target | P21. |
| Invitro | 6-CEPN (10-100 μM, 24 h) 在 SW620、SW480、HCT116 和 HT29 细胞中以浓度依赖方式降低细胞活性，能够抗细胞增殖[1]。6-CEPN (10 μM, 24 h) 在 SW620 和 HCT116 细胞中能将细胞周期阻滞在 G1 期[1]。6-CEPN (10 μM, 24 h) 在 SW620 和 HCT116 细胞中能诱导细胞坏死[1]。6-CEPN (2.5-10 μM, 24 h) 在 SW620 和 HCT116 细胞中通过抑制 RAS 激活的方式来诱导结肠癌细胞自噬和细胞死亡[1]。 0 --> 6-CEPN 相关抗体: Cell Cycle Analysis[1] Cell Line: |
| Name | 6-CEPN |
| CAS | 1054549-73-3 |
| Formula | C23H18O5 |
| Molar Mass | 374.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao Y, et al. 6-C-(E-phenylethenyl)naringenin induces cell growth inhibition and cytoprotective autophagy in colon cancer cells[J].European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR), 2016, 68(Null). |