6,4'-Dihydroxy-7-methoxyflavanone_product_DataBase

Bioactivity	6,4'-Dihydroxy-7-methoxyflavanone, a flavonoid, is a nature product that could be isolated from Heartwood Dalbergia odorifera. 6,4'-Dihydroxy-7-methoxyflavanone inhibits receptor activators of nuclear factor kappa-B ligand (RANKL) induced osteoclastogenesis. 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in research of osteoporosis[1].
Invitro	6,4'-Dihydroxy-7-methoxyflavanone（3-30 µM；巨噬细胞）以剂量依赖性方式抑制破骨细胞生成和 TRAP 活性[1]。6,4'-Dihydroxy-7-methoxyflavanone（0-30 µM；48 小时）会破坏成熟破骨细胞的肌动蛋白环形成[1]。6,4'-Dihydroxy-7-methoxyflavanone（0-30 µM；1 小时；巨噬细胞）通过抑制作用抑制 RANKL 诱导的活化 T 细胞核因子、细胞质、钙调神经磷酸酶依赖性 1 (NFATc1) 和 c-Fos 的表达丝裂原激活蛋白激酶 (MAPK) 通路[1]。 Western Blot Analysis[1] Cell Line:
Name	6,4'-Dihydroxy-7-methoxyflavanone
CAS	189689-32-5
Formula	C16H14O5
Molar Mass	286.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Im NK, et, al. 6,4'-Dihydroxy-7-methoxyflavanone inhibits osteoclast differentiation and function. Biol Pharm Bull. 2013;36(5):796-801.

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