| Bioactivity | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. | ||||||||||||
| Invitro | Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2]. | ||||||||||||
| Name | 5α-Pregnane-3β,6α-diol-20-one | ||||||||||||
| CAS | 21853-11-2 | ||||||||||||
| Formula | C21H34O3 | ||||||||||||
| Molar Mass | 334.49 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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5α-Pregnane-3β,6α-diol-20-one
CAS: 21853-11-2 F: C21H34O3 W: 334.49
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-r
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