| Bioactivity | 5HT6-ligand-2 (compound 15) is a potent 5-HT6 inhibitor with Ki values of 3.4, 15 nM for 5-HT6, SERT, respectively. 5HT6-ligand-2 shows neuroprotection. 5HT6-ligand-2 has the potential for the research of dementia[1]. |
| In Vivo | BET-IN-26 (compound 13a) (10, 100 mg/kg; p.o.) 以剂量依赖性方式降低小鼠中 LPS (HY-D1056) 诱导的血清 IL-6 和 MCP-1 水平[1]。药代动力学分析 (2.5 mg/kg; i.p.; Male Wistar rats)[1]. Parameter |
| Formula | C29H28N6O |
| Molar Mass | 476.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Siwek A, et al. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties. Eur J Med Chem. 2024 Sep 5;275:116601. |