| Bioactivity | 5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1]. |
| CAS | 1616344-00-3 |
| Formula | C13H22O5 |
| Molar Mass | 258.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chirackal S, et al. Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide[J]. Blood, 2019, 134: 4410. |
5-Octyl-α-ketoglutarate
CAS: 1616344-00-3 F: C13H22O5 W: 258.31
5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-k
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