| Bioactivity | 5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1]. |
| Invitro | 5-O-Methylembelin（compound 3；20 μM；24 小时）显着下调 PCSK9（IC50 值为 4.9 μM）、IDOL 和 SREBP2 mRNA 表达[1]。 RT-PCR[1] Cell Line: |
| Name | 5-O-Methylembelin |
| CAS | 56005-10-8 |
| Formula | C18H28O4 |
| Molar Mass | 308.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305. |
5-O-Methylembelin
CAS: 56005-10-8 F: C18H28O4 W: 308.41
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, low-density lipoprotein receptor (IDOL), and sterol regu
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