| Bioactivity | 5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP[1][2]. |
| Target | Melatonin MT3 receptor |
| Name | 5-MCA-NAT |
| CAS | 190277-13-5 |
| Formula | C14H17N3O3 |
| Molar Mass | 275.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121(8):1775-81. [2]. Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13(5):385-8. |
5-MCA-NAT
CAS: 190277-13-5 F: C14H17N3O3 W: 275.30
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a
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