5-LOX-IN-6_product_DataBase

Bioactivity	5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research[1].
Invitro	5-LOX-IN-6 (compound 11a) (0-10 µM) 可有效阻断人全血测定中 5-LO 产物的形成 (IC50=0.83-1.6 µM)[1]。5-LOX-IN-6 (0-10 µM) 无法阻断 A23187 (HY-N6687，2.5 µM) 诱导的中性粒细胞中 5-LO 易位[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 5-LOX-IN-6 相关抗体:
In Vivo	5-LOX-IN-6 (compound 11a) (4 mg/kg，腹腔注射)可显著阻止 λ-carrageenan (HY-N9470) 治疗的大鼠胸腔渗出物中白三烯 B4 的产生，胸膜炎严重程度降低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1159576-98-3
Formula	C22H18ClNO3
Molar Mass	379.84
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Karg EM, et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83.

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