5-LO/mPGES-1-IN-1_product_DataBase

Bioactivity	5-LO/mPGES-1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES-1-IN-1 has anti-inflammatory activity[1].
In Vivo	5-LO/mPGES-1-IN-1 (10 mg/kg, 腹腔注射, 腹膜炎诱导前 30 分钟预处理) 在 zymosan 诱导的小鼠腹膜炎模型中，可降低血管通透性和炎症细胞浸润，并伴有半胱氨酸-白三烯和前列腺素 E2 水平受损[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1492060-44-2
Formula	C25H25ClN4O2S2
Molar Mass	513.07
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hanke T, et al. Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo. J Med Chem. 2013 Nov 27;56(22):9031-44.

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