| Bioactivity | 5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1]. |
| Name | 5-Iodoresiniferatoxin |
| CAS | 535974-91-5 |
| Formula | C37H39IO9 |
| Molar Mass | 754.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Seabrook GR, et, al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60. [2]. Shimizu I, et, al. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85. |
5-Iodoresiniferatoxin
CAS: 535974-91-5 F: C37H39IO9 W: 754.60
5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human recepto
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