Bioactivity | 5-Hydroxyindole-3-acetic acid-d5is the deuterium labeled5-Hydroxyindole-3-acetic acid(HY-W008253)[1]. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors[2]. |
Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注,因为它可能影响药物的药代动力学和代谢谱[1]。 |
Name | 5-Hydroxyindole-3-acetic acid-d5 |
CAS | 81587-11-3 |
Formula | C10H4D5NO3 |
Molar Mass | 196.21 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. |