| Bioactivity | 5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A) and 5786 nM (5-HT2A), respectively. 5-HT7R antagonist 3 possesses antidepressant and anxiolytic effects in mice[1]. |
| Invitro | 5-HT7R antagonist 3 (1 pM-1 μM) 可抑制稳定表达人 5-HT 的细胞中 cAMP 产生，其IC50 为 113 nM，Kb 为 14 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 5-HT7R antagonist 3 相关抗体: |
| In Vivo | 5-HT7R antagonist 3 (1.25-10 mg/kg，腹腔注射，测试前 60 min) 在雄性 BalbC 小鼠 (20-25 g) 中发挥显著的抗焦虑和抗抑郁作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1887043-58-4 |
| Formula | C30H33FN4O3 |
| Molar Mass | 516.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kucwaj-Brysz K, et al. The Importance of Stereochemistry in 5-HT7R Modulation─A Case Study of Hydantoin Derivatives. ACS Chem Neurosci. 2024;15(21):3884-3900. |
5-HT7R antagonist 3
CAS: 1887043-58-4 F: C30H33FN4O3 W: 516.61
5-HT7R antagonist 3 (Compound 6.4) is a selective 5-HT7R antagonist (Ki: 8 nM), with Ki of 511 nM (D2), 8930 nM (5-HT1A)
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