| Bioactivity | 5-HT1AR agonist 2 (Compound 4f) is a 5-HT1A receptor agonist (Ki: 10.0 nM). 5-HT1AR agonist 2 also binds to the SERT, D2 receptor and 5-HT6 receptor (Ki: SERT, 2.8 nM; D2, 23 nM; 5-HT6, 192 nM). 5-HT1AR agonist 2 is stabilized in microsomes and induces hypothermia in mice[1]. |
| Invitro | 5-HT1AR agonist 2 (10 μM) 在人微粒体中表现出高度稳定性，其内在清除率低于 115.5 μL/ min/mg，t1/2 高于 209 min[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 5-HT1AR agonist 2 相关抗体: |
| In Vivo | 5-HT1AR agonist 2 (5-20 mg/kg, i.p., 测试前 30 min) 以类似 8-OH-DPAT (HY-112061) 方式诱导雄性 CD-1 小鼠体温过低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C31H31N5O3 |
| Molar Mass | 521.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Siwek, et al. Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT. Bioorganic chemistry, 2023, 141, 106903. |