5'-Guanylic acid-15N5,d12 dilithium_product_DataBase

Bioactivity	5'-Guanylic acid-15N5,d12 (5'-GMP-15N5,d12 dilithium; 5'-guanosine monophosphate-15N5,d12) dilithium is deuterium and 15N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 0 --> 5'-Guanylic acid-15N5,d12 dilithium 相关抗体:
Name	5'-Guanylic acid-15N5,d12 dilithium
Formula	C10D12Li215N5O8P
Molar Mass	392.13
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

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