| Bioactivity | 5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist[1][2][3]. |
| Invitro | [3H]-5-Carboxamidotryptamine (5-CT) binding to 5-HT1D sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (Kd = 0.38 nM) and low non-specific binding[2]. In bovine substantia nigra, [3H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [3H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides[2]. |
| In Vivo | Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone)[1]. |
| Name | 5-Carboxamidotryptamine maleate |
| CAS | 74885-72-6 |
| Formula | C15H17N3O5 |
| Molar Mass | 319.31 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. E Martínez-García, et al. 5-HT7 receptor-mediated meningeal dilatation induced by 5-carboxamidotryptamine in rats is not altered by 5-HT depletion and chronic corticosterone treatment. Proc West Pharmacol Soc. 2011;54:57-61. [2]. H P Nowak, et al. [3H]-5-carboxamidotryptamine labels 5-HT1D binding sites in bovine substantia nigra. Br J Pharmacol. 1993 Aug;109(4):1206-11. [3]. J Yamada, et al. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats. Eur J Pharmacol. 1998 Oct 16;359(1):81-6. |
5-Carboxamidotryptamine maleate
CAS: 74885-72-6 F: C15H17N3O5 W: 319.31
5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist.
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