| Bioactivity | 4F-DDC is a novel PARP1 inhibitor with an IC50 value of 82 nM. 4F-DDC induces DNA damage and activates the cGAS–STING pathway. 4F-DDC inhibits the growth of HCC-1937-derived tumor xenografts[1]. |
| Formula | C16H14Br2FN3O2S |
| Molar Mass | 491.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yonglong Jin, et al. A Novel Inhibitor of Poly(ADP- R ibose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line via the DNA D amage- A ctivated cGAS-STING Pathway. Chem Res Toxicol. 2024, 37, 4. |