| Bioactivity | 4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model[1]. |
| In Vivo | 4A3-SC8 在静脉注射 1mg siRNA/kg 24 小时后介导 siRNA 主要在肝脏中积聚，少量在脾脏和肾脏中积聚，并使小鼠 >95% 的 FVII 被敲低[1]。4A3-SC8 (100 mg/kg with 4 mg/kg control siRNA siCTR; i.v.; once) 注射后，老鼠生病并在注射后的第一天体重下降了近 20%[1]。 |
| Name | 4A3-SC8 |
| CAS | 1857340-78-3 |
| Formula | C75H139N3O16S4 |
| Molar Mass | 1467.18 |
| Appearance | Oil |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Zhou K, et al. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):520-5. |
4A3-SC8
CAS: 1857340-78-3 F: C75H139N3O16S4 W: 1467.18
4A3-SC8 is a modular degradable dendrimer that enables small RNAs to extend survival in an aggressive liver cancer model
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