4-hydroxy Nonenal Mercapturic Acid_product_DataBase

Bioactivity	4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
CAS	146764-24-1
Formula	C14H25NO5S
Molar Mass	319.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Laurent, et al. Analysis in the rat of 4-hydroxynonenal metabolites excreted in bile: Evidence of enterohepatic circulation of these byproducts of lipid peroxidation. Chem. Res. Toxicol. 12(10), 887-894 (1999).

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