| Bioactivity | 4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3]. |
| Invitro | 4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3]. |
| In Vivo | 4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2]. Animal Model: |
| Name | 4-PPBP maleate |
| CAS | 201216-39-9 |
| Formula | C25H31NO4 |
| Molar Mass | 409.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. [2]. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. [3]. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424. |
4-PPBP maleate
CAS: 201216-39-9 F: C25H31NO4 W: 409.52
4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA
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