4-Hydroxymidazolam

CAS: 59468-85-8 F: C18H13ClFN3O W: 341.77

4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.

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Bioactivity	4-Hydroxymidazolam is a major metabolite of Midazolam. Midazolam is a potent benzodiazepine with anxiolytic properties.
Invitro	Midazolam is metabolized to 1'- and 4-hydroxymidazolam by CYP3A4 and CYP3A5 and is further metabolized to glucuronide conjugates by UDP-glucuronosyltransferases (UGTs)[1].
Name	4-Hydroxymidazolam
CAS	59468-85-8
Formula	C18H13ClFN3O
Molar Mass	341.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Seo KA, et al. Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Drug Metab Dispos. 2010 Nov;38(11):2007-13.