4'-Hydroxy flurbiprofen_product_DataBase

Bioactivity	4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM[1].
Invitro	4'-Hydroxy flurbiprofen 不能抑制 COX-1 和 COX-2 催化的花生四烯酸氧合，但在 300 µM 浓度下完全抑制 2-花生四烯酰甘油 (2-AG) 的环氧合，在 100 µM 和 30 µM 浓度下部分抑制[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 4'-Hydroxy flurbiprofen 相关抗体:
CAS	52807-12-2
Formula	C15H13FO3
Molar Mass	260.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Karlsson J, Fowler CJ. Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen. PLoS One. 2014 Jul 25;9(7):e103589. [2]. Tracy TS, et al. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 1996 Oct 25;52(8):1305-9.

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