Bioactivity | 4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. |
Invitro | 4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. Cell Viability Assay[1] Cell Line: |
Name | 4-Formylcolchicine |
CAS | 2730-82-7 |
Formula | C23H25NO7 |
Molar Mass | 427.45 |
Appearance | Solid |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
Reference | [1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52. |