| Bioactivity | 4-FPBUA is a semisynthetic analog of usnic acid (HY-W015883) that can enhance cellular blood-brain barrier (BBB) function and increase the transport of Amyloid β (Aβ) across monolayer cells. 4-FPBUA is also an inhibitor of mTOR, capable of enhancing cellular Autophagy, thereby reversing BBB disruption in vivo and being utilized in research for Alzheimer's disease[1]. |
| CAS | 2089636-93-9 |
| Formula | C31H23FO7 |
| Molar Mass | 526.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Al Rihani S B, et al. The Usnic Acid Analogue 4-FPBUA Enhances the Blood–Brain Barrier Function and Induces Autophagy in Alzheimer’s Disease Mouse Models[J]. ACS Chemical Neuroscience, 2024. |