4-Butyl-alpha-agarofuran_product_DataBase

Bioactivity	4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research[1].
Invitro	在人肝微粒体培养体系中，4-Butyl-alpha-agarofuran (2 mg) 在 100 分钟内完全代谢为羟基衍生物 I 和羰基衍生物 II[2]。
In Vivo	4-Butyl-alpha-agarofuran (0.5-10 mg/kg；腹腔注射，1 次) 在社交互动测试中显示出抗焦虑作用，显著降低纹状体、皮层和中脑的血清素 (5-HT) 水平[1]。 Animal Model:
Name	4-Butyl-alpha-agarofuran
CAS	272126-07-5
Formula	C18H30O
Molar Mass	262.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang Y, et al. Effects of novel anxiolytic 4-butyl-alpha-agarofuran on levels of monoamine neurotransmitters in rats. Eur J Pharmacol. 2004 Nov 3;504(1-2):39-44. [2]. Li N, et al. [In vitro metabolic studies of the novel anti-anxietic drug AF-5 and its metabolites in human liver microsome incubation system]. Yao Xue Xue Bao. 2001 Jul;36(7):528-31. Chinese.

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