4,5-Dicaffeoylquinic acid_product_DataBase

Bioactivity

4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) is an antioxidant, can be isolated from Gynura divaricata and Laggera alata. 4,5-Dicaffeoylquinic acid reduces islet cell apoptosis and improves pancreatic function in type 2 diabetic mice, and has obvious inhibitory activities against yeast α-glucosidase. 4,5-Dicaffeoylquinic acid inhibits prostate cancer cells through cell cycle arrest. 4,5-Dicaffeoylquinic acid also has anti-apoptotic, anti-injury and anti-hepatitis B virus effects[1][2][3].

Invitro

4,5-Dicaffeoylquinic acid (0.1~100 µM; 72 h) has dose-dependent inhibitory activity against DU-145 prostate cancer cells, and induces cell cycle arrest, also induces inactivation of Bcl-2[2].4,5-Dicaffeoylquinic acid (1~100 µg/mL; 48 h) has anti-apoptotic effect in D-GalN-challenged HL-7702 hepatocytes, and improves significantly cell viability at concentrations of 10 to 100 µg/mL[3].4,5-Dicaffeoylquinic acid (1~100 µg/mL; 4 days) inhibits significantly expressions of HBsAg and HBeAg, and produces the maximum inhibition rates of 86.93 and 59.79% at 100 µg/mL on expressions of HBsAg and HBeAg, respectively[3]. Cell Proliferation Assay[2] Cell Line:

Name

4,5-Dicaffeoylquinic acid

CAS

57378-72-0

Formula

C25H24O12

Molar Mass

516.45

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

4,5-Dicaffeoylquinic acid

CAS: 57378-72-0 F: C25H24O12 W: 516.45