| Bioactivity | 4,4'-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM. | ||||||||||||
| Target | Ki: 70 nM (hiCE) | ||||||||||||
| Invitro | By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4'-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed[1]. | ||||||||||||
| Name | 4,4'-Dimethoxybenzil | ||||||||||||
| CAS | 1226-42-2 | ||||||||||||
| Formula | C16H14O4 | ||||||||||||
| Molar Mass | 270.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. GuoDong Zhang, et al. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands. Science China Chemistry |