| Bioactivity | 3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer[1]. | ||||||||||||
| CAS | 294891-81-9 | ||||||||||||
| Formula | C22H18N2O4 | ||||||||||||
| Molar Mass | 374.39 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Grandy D, et al. Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled[J]. Journal of Biological Chemistry, 2009, 284(24): 16256-16263. |