| Bioactivity | 3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL)[1]. |
| CAS | 6869-66-5 |
| Formula | C26H32O6 |
| Molar Mass | 440.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He X, Tang J, Qiao A, et al. Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus Niger[J]. Steroids, 2006, 71(5): 392-402. |
3-Oxo-cinobufagin
CAS: 6869-66-5 F: C26H32O6 W: 440.53
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by
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