| Bioactivity | 3'-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 µM, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer[1]. |
| Invitro | 3'-Hydroxypterostilbene (5-50 μM; 24 h) affects cell proliferation of COLO 205, HCT-116 and HT-29[1].3'-Hydroxypterostilbene (5-100 μM; 24 h) induces cell apoptosis and the concentration of ROS plays an important role as an early mediator in 3'-Hydroxypterostilbene-induces apoptosis[1].3'-Hydroxypterostilbene (5-50 μM; 24 h) induces caspase-9 cleavage, increases caspase-3 activity and inhibits the mTOR/p70S6K, PI3K/Akt and MAPKs signaling pathways in COLO 205 cells[1].3'-Hydroxypterostilbene (25-50 μM; 24 h) induces autophagy in COLO 205 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | 3'-Hydroxypterostilbene |
| CAS | 475231-21-1 |
| Formula | C16H16O4 |
| Molar Mass | 272.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
3'-Hydroxypterostilbene
CAS: 475231-21-1 F: C16H16O4 W: 272.30
3'-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205,
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