| Bioactivity | 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1]. | ||||||||||||
| Invitro | 3-Hydroxykynurenine-induced neuronal cell death shows several features of apoptosis[1]. 3-Hydroxykynurenine is a metabolic intermediate of the kynurenine pathway, the major metabolic pathway of tryptophan (Trp)[1].3-Hydroxykynurenine acts as an endogenous neurotoxin in the brain under pathological conditions[1]. 3-Hydroxykynurenine (20-100 μM) significantly inhibits CD4+ T-cell proliferation in a dose-dependent manner with IC50 of approximately 70 μM[2].3-Hydroxykynurenine (20-100 μM) induces significant CD4+ T-cell-mediated cell death in a dose-dependent manner[2]. Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | 3-Hydroxykynurenine | ||||||||||||
| CAS | 484-78-6 | ||||||||||||
| Formula | C10H12N2O4 | ||||||||||||
| Molar Mass | 224.21 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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3-Hydroxykynurenine
CAS: 484-78-6 F: C10H12N2O4 W: 224.21
3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been
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