3-Fluoro-evodiamine glucose

CAS: F: C25H26FN3O7 W: 499.49

3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the e

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Bioactivity	3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity[1].
Invitro	3-Fluoro-evodiamine glucose (0-0.5 μM，12 h) 通过诱导活性氧 (ROS) 积累和 DNA 损伤，在癌细胞 U87MG、A549 和 HCT116 中表现出抗增殖活性和细胞毒性，IC50 为 0.064–0.113 μM[1]。3-Fluoro-evodiamine glucose (0-0.05 μM，24 h) 剂量依赖地抑制 HCT116 细胞的迁移和侵袭[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 3-Fluoro-evodiamine glucose 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	3-Fluoro-evodiamine glucose (10 mg/kg，腹腔注射，单剂量) 在小鼠体内表现出良好的药代动力学特性，半衰期为 2.41 h，血浆暴露度 Cmax 为 4627 h·ng/ mL，AUC0-t 为 4008 h·ng/mL，平均停留时间为 0.802 h[1]。3-Fluoro-evodiamine glucose (10-20 mg/kg，腹腔注射，每天两次，持续 21 天) 在 HCT116 异种移植裸鼠中表现出抗肿瘤功效，肿瘤生长抑制率 TGI 为 72%-82%，且无明显毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C25H26FN3O7
Molar Mass	499.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wu Z, et al., Design of Evodiamine-Glucose Conjugates with Improved In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67(9):7373-7384.