| Bioactivity | 3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchicine has the same effects and activities as colchicine in blocking casein-induced amyloidosis, microtubule binding, and anti-inflammatory effects, with significantly lower toxicity[1][2]. | ||||||||||||
| CAS | 87424-25-7 | ||||||||||||
| Formula | C21H23NO5S | ||||||||||||
| Molar Mass | 401.48 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kerkes P, et al. Synthesis and biological effects of novel thiocolchicines. 3. Evaluation of N-acyldeacetylthiocolchicines, N-(alkoxycarbonyl) deacetylthiocolchicines, and O-ethyldemethylthiocolchicines. New synthesis of thiodemecolcine and antileukemic effects of 2-demethyl-and 3-demethylthiocolchicine[J]. Journal of medicinal chemistry, 1985, 28(9): 1204-1208. [2]. Wolach B, et al. Colchicine analogues: effect on amyloidogenesis in a murine model and, in vitro, on polymorphonuclear leukocytes[J]. European journal of clinical investigation, 1992, 22(9): 630-634. |
3-Demethylthiocolchicine
CAS: 87424-25-7 F: C21H23NO5S W: 401.48
3-Demethylthiocolchicine is a colchicine (HY-16569) analog with broad-spectrum antitumor activity. 3-Demethylthiocolchic
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