3-Deazauridine_product_DataBase

Bioactivity	3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier[1].
Target	Cytidine triphosphate synthase
Invitro	3-Deazauridine (DAUR) 对 L1210 白血病细胞具有优异的抗肿瘤活性[1]。
In Vivo	3-Deazauridine (DAUR) (250 mg/kg/天；腹腔注射；1-9 天) 对小鼠中的 L1210 白血病细胞显示出中等活性[1]。3-Deazauridine (腹腔注射；给药 5 次) 对比格犬和恒河猴的致死剂量分别为 250 mg/kg/day 和 417 mg/kg/day，最低毒性剂量为 62.5 mg/kg/day 和 104 mg/kg/day，无毒剂量分别为 31.25 mg/kg/day 和 52 mg/kg/day[1]。
Name	3-Deazauridine
CAS	23205-42-7
Formula	C10H13NO6
Molar Mass	243.21
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Moriconi WJ, et al. 3-Deazauridine (NSC 126849): an interesting modulator of biochemical response. Invest New Drugs. 1986;4(1):67-84.

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