| Bioactivity | 3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1]. | ||||||||||||
| Invitro | 3-Chloro-5-hydroxybenzoic acid shows potency against human (EC50=16 μM), monkey (EC50=17 μM), dog (EC50=67 μM), rat (EC50=7 μM), mouse (EC50=22 μM), and hamster GPR81 (EC50=27 μM)[1]. | ||||||||||||
| In Vivo | 3-Chloro-5-hydroxybenzoic acid (30, 100, and 300 mg/kg; PO in overnight fasted C57Bl6/J mice fed high fat chow for 10 weeks) shows significant reductions in free fatty acids at all doses tested, resulting in a minimum efficacious dose of 30 mg/kg[1].Pharmacokinetic Parameters of 3-Chloro-5-hydroxybenzoic acid in Mice[1]. dose (mg/kg) | ||||||||||||
| Name | 3-Chloro-5-hydroxybenzoic acid | ||||||||||||
| CAS | 53984-36-4 | ||||||||||||
| Formula | C7H5ClO3 | ||||||||||||
| Molar Mass | 172.57 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Dvorak CA, et al. Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett. 2012;3(8):637-639. Published 2012 Jun 11. |
3-Chloro-5-hydroxybenzoic acid
CAS: 53984-36-4 F: C7H5ClO3 W: 172.57
3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of
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