| Bioactivity | 3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities[1][2][3]. |
| Invitro | 3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells[2].3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress[2].3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels[2]. Cell Viability Assay[2] Cell Line: |
| Name | 3-Bromopyruvic acid |
| CAS | 1113-59-3 |
| Formula | C3H3BrO3 |
| Molar Mass | 166.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
3-Bromopyruvic acid
CAS: 1113-59-3 F: C3H3BrO3 W: 166.96
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.