3,4,5-Trihydroxycinnamic acid decyl ester_product_DataBase

Bioactivity

3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM[1].

Target

EC50: 0.9 μM (pancreatic lipase)

Invitro

3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro[1].3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC50 value being approximately 0.9 μM[1].3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation[1].

In Vivo

3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally[1]. Animal Model:

Name

3,4,5-Trihydroxycinnamic acid decyl ester

CAS

1770778-45-4

Formula

C19H28O5

Molar Mass

336.42

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Masahiko Imai ,et al. Inhibitory effects of hydroxylated cinnamoyl esters on lipid absorption and accumulation. Bioorg Med Chem. 2015 Jul 1;23(13):3788-95.

PeptideDB

3,4,5-Trihydroxycinnamic acid decyl ester

CAS: 1770778-45-4 F: C19H28O5 W: 336.42