| Bioactivity | 2'-Thioadenosine is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1]. |
| Invitro | 2'-Thioadenosine (50 µM) 对 FGF，PDGF 和胰岛素受体酪氨酸激酶没有活性[1]。2'-Thioadenosine 使 ErbB-1 共价失活，这种失活可被 1 mM Dithiothreitol 逆转[1]。 |
| Name | 2′-Thioadenosine |
| CAS | 136904-69-3 |
| Formula | C10H13N5O3S |
| Molar Mass | 283.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Singh J, et, al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40(7):1130-5. |
2′-Thioadenosine
CAS: 136904-69-3 F: C10H13N5O3S W: 283.31
2'-Thioadenosine is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-T
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