2′-Hydroxychalcone-1_product_DataBase

Bioactivity

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

Invitro

2'-Hydroxychalcone（10-90 μM；12-72 h）以剂量依赖性方式抑制细胞活力，对于两种乳腺癌细胞系 MCF-7 和 CMT-1211 的 IC50 值分别为 37.74 μM 和 34.26 μM [1]。 2'-Hydroxychalcone（10-30 μM；24 小时）促进乳腺癌细胞自噬囊泡积聚[1]。2'-Hydroxychalcone（30 μM；24 小时）可诱导乳腺癌细胞发生自噬依赖性细胞凋亡，并增加 caspase-3 和 PARP 的裂解[1]。2′-Hydroxychalcone（10-30 μM；24 小时）显着降低 p-IκB 和 p-NF-κBp65 的表达，并提高 p-ERK 和 p-JNK 的水平[1]。2'-Hydroxychalcone（30 μM；12-24 小时）可增加乳腺癌细胞的细胞内 ROS 水平并触发内质网应激[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 2′-Hydroxychalcone-1 相关抗体: Cell Viability Assay[1] Cell Line:

In Vivo

2'-Hydroxychalcone（20-60 mg/kg；腹腔注射；每 2 天；3 周）可在体内表现出抗肿瘤作用，而不会对重要器官造成明显毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

CAS

1214-47-7

Formula

C15H12O2

Molar Mass

224.25

Appearance

固体

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16(4):514. [2]. Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33.

PeptideDB

2′-Hydroxychalcone-1

CAS: 1214-47-7 F: C15H12O2 W: 224.25

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PeptideDB

2′-Hydroxychalcone-1

CAS: 1214-47-7 F: C15H12O2 W: 224.25

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